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Repair of a Large Ventral Hernia in a Rhesus Macaque (Macaca mulatta) by Using an Abdominal Compo...
Repair of a Large Ventral Hernia in a Rhesus Macaque (Macaca mulatta) by Using an Abdominal Compo...
Here we present a 32-y-old rhesus macaque (Macaca mulatta) with a large recurrent ventral incisional hernia. The initial surgery included midline celiotomy for treatment of endometriosis, in which the animal developed a hernia that was repaired with in...
Humane Endpoints for Guinea Pigs Used for Mycobacterium tuberculosis Vaccine Research
Humane Endpoints for Guinea Pigs Used for Mycobacterium tuberculosis Vaccine Research
Guinea pigs are a commonly used model for tuberculosis vaccine research. Loss of body weight is the most frequently described humane endpoint for animals used in these studies. During a chronic study, we noted labored breathing in some tuberculosis-inf...
Effect of Prepregnancy Obesity on Litter Size in Primiparous Minipigs
Effect of Prepregnancy Obesity on Litter Size in Primiparous Minipigs
Obesity is a public health problem in both developed and developing countries, and the negative effects of obesity on reproductive physiology have been highlighted recently.
Systemic Iron Deficiency in a Nonhuman Primate Model of Endometriosis
Systemic Iron Deficiency in a Nonhuman Primate Model of Endometriosis
Endometriosis is characterized by endometrial tissue development outside the uterus. Anemia and iron depletion do not commonly accompany endometriosis in women, despite chronic abdominal inflammation and heavy menstrual bleeding.
Evaluation of 6 Methods for Aerobic Bacterial Sanitization of Smartphones
Evaluation of 6 Methods for Aerobic Bacterial Sanitization of Smartphones
Smartphones are ubiquitous devices that offer a variety of useful applications for human and veterinary medical professionals and the biomedical research community. Smartphones can serve as fomites and potentially transmit pathogens, including bacteria...
Reproductive Performance after Unilateral or Bilateral Oviduct Transfer of 2-Cell Embryos in Mice
Reproductive Performance after Unilateral or Bilateral Oviduct Transfer of 2-Cell Embryos in Mice
Embryo transfer (ET) is a frequent procedure in contemporary animal and transgenic facilities.
Content loaded within last 14 daysExtending the Use of Disposable Caging Based on Results of Micr...
Content loaded within last 14 daysExtending the Use of Disposable Caging Based on Results of Micr...
Prions are proteinaceous infectious agents that are highly resistant to denaturation. Sterilization of prion-contaminated mouse cages requires chemical agents and increased autoclave temperatures that damage traditional cages, thus increasing facility ...
Longitudinal Anthropometric Assessment of Rhesus Macaque (Macaca mulatta) Model of Huntington Dis...
Longitudinal Anthropometric Assessment of Rhesus Macaque (Macaca mulatta) Model of Huntington Dis...
The neurodegeneration associated with Huntington disease (HD) leads to the onset of motor and cognitive impairment and their advancement with increased age in humans.
Standard Electrocardiographic Data from Capuchin Monkeys
Standard Electrocardiographic Data from Capuchin Monkeys
Capuchin monkeys are a species of arboreal primate found in all South American countries. These monkeys have been highlighted for their potential for biomedical research due to their anatomic and physiologic similarities and genetic homology with humans.
Comparative Review of Antimicrobial Resistance in Humans and Nonhuman Primates
Comparative Review of Antimicrobial Resistance in Humans and Nonhuman Primates
Antimicrobial resistance (AMR) presents serious threats to human and animal health. Although AMR of pathogens is often evaluated independently between humans and animals, comparative analysis of AMR between humans and animals is necessary for zoonotic ...
Silicon Foreign Body in the Cerebrum of a Rhesus Macaque (Macaca mulatta)
Silicon Foreign Body in the Cerebrum of a Rhesus Macaque (Macaca mulatta)
A male rhesus macaque with a cephalic chamber implant for neurophysiology recording presented with hemiparesis affecting the left thoracic and pelvic limbs at approximately 5 wk after craniotomy surgery.
Methods for Investigating the Motivation of Mice to Explore and Access Food Rewards
Methods for Investigating the Motivation of Mice to Explore and Access Food Rewards
The emotional state of domestic animals is an essential component of the assessment of their welfare. In addition, sensitivity to various rewards can be a valuable indicator when investigating these states.
EZH2 Expression in Naturally Occurring Canine Tumors
EZH2 Expression in Naturally Occurring Canine Tumors
Enhancer of zeste homolog 2 (EZH2) shows upregulated expression in tumors and is an important driver of tumor development and progression. However, the mechanism underlying the mediation of tumor aggressiveness by EZH2 remains unclear.
Comparison of Etomidate, Benzocaine, and MS222 Anesthesia with and without Subsequent Flunixin Me...
Comparison of Etomidate, Benzocaine, and MS222 Anesthesia with and without Subsequent Flunixin Me...
Often few alternative anesthetics for exotic species are available, due to the small numbers of these animals used in research.In this study, we evaluated the depth and duration of anesthesia in Xenopus laevis after their immersion in 3 doses of etomid...
Methods for Investigating the Motivation of Mice to Explore and Access Food Rewards
Methods for Investigating the Motivation of Mice to Explore and Access Food Rewards
The emotional state of domestic animals is an essential component of the assessment of their welfare. In addition, sensitivity to various rewards can be a valuable indicator when investigating these states.
Animal Models of Aspergillosis
Animal Models of Aspergillosis
Aspergillosis is an airborne fungal disease caused by Aspergillus spp., a group of ubiquitous molds. This disease causes high morbidity and mortality in both humans and animals.
Retrospective Review of Surgical Outcomes and Pair-housing Success in Vasectomized Rhesus Macaque...
Retrospective Review of Surgical Outcomes and Pair-housing Success in Vasectomized Rhesus Macaque...
Providing social housing for adult male macaques can be challenging. One successful strategy for long-term social housing of adult male macaques is to pair them with adult females; however, unwanted breeding must be prevented by sterilization of the ma...
Effect of Daytime Blue-enriched LED Light on the Nighttime Circadian Melatonin Inhibition of Hepa...
Effect of Daytime Blue-enriched LED Light on the Nighttime Circadian Melatonin Inhibition of Hepa...
Liver cancer is the second leading cause of cancer death worldwide. Metabolic pathways within the liver and liver cancers are highly regulated by the central circadian clock in the suprachiasmatic nuclei (SCN).
Out Like a Light? The Effects of a Diurnal Husbandry Schedule on Mouse Sleep and Behavior
Out Like a Light? The Effects of a Diurnal Husbandry Schedule on Mouse Sleep and Behavior
Sleep disruption in humans, caused by shift work, can be detrimental to physical and behavioral health. Nocturnal laboratory mice may experience a similar disruption caused by human daytime activities, but whether this disruption affects their welfare ...
Effectiveness of Rapid Cooling as a Method of Euthanasia for Young Zebrafish (Danio rerio)
Effectiveness of Rapid Cooling as a Method of Euthanasia for Young Zebrafish (Danio rerio)
Despite increased use of zebrafish (Danio rerio) in biomedical research, consistent information regarding appropriate euthanasia methods, particularly for embryos, is sparse. Current literature indicates that rapid cooling is an effective method of eut...
Role of Wild-type and Recombinant Human T-cell Leukemia Viruses in Lymphoproliferative Disease in...
Role of Wild-type and Recombinant Human T-cell Leukemia Viruses in Lymphoproliferative Disease in...
Chronic infection with human T-cell leukemia virus type 1 (HTLV1) can lead to adult T-cell leukemia (ATL). In contrast, infection with HTLV2 does not lead to leukemia, potentially because of distinct virus�host interactions and an active immune respons...
Analgesic Efficacy of Subcutaneous�Oral Dosage of Tramadol after Surgery in C57BL/6J Mice
Analgesic Efficacy of Subcutaneous�Oral Dosage of Tramadol after Surgery in C57BL/6J Mice
This study investigated the analgesic activity of tramadol in female C57BL/6J mice by using a single subcutaneous injection (25 mg/kg) of tramadol combined with the same dose given in drinking water for 24 h. We then evaluated the pharmacokinetics of t...
Evaluation of a Commercially Available Euthanasia Solution as a Voluntarily Ingested Euthanasia A...
Evaluation of a Commercially Available Euthanasia Solution as a Voluntarily Ingested Euthanasia A...
All currently accepted methods of euthanasia for laboratory mice involve some degree of stress, fear, anxiety, or pain. We evaluated the voluntary oral administration of a euthanasia drug in 99 male and 81 female mice of various strains.
Evaluation of Volume of Intramuscular Injection into the Caudal Thigh Muscles of Female and Male ...
Evaluation of Volume of Intramuscular Injection into the Caudal Thigh Muscles of Female and Male ...
This study presents recommendations for intramuscular injection into the caudal thigh muscle of mice according to analysis of in vivo imaging of intramuscularly injected iohexol, a radiocontrast agent commonly used in CT imaging.
Reproductive Performance after Unilateral or Bilateral Oviduct Transfer of 2-Cell Embryos in Mice
Reproductive Performance after Unilateral or Bilateral Oviduct Transfer of 2-Cell Embryos in Mice
Embryo transfer (ET) is a frequent procedure in contemporary animal and transgenic facilities. We compared the reproductive performance of mice after unilateral and bilateral ET of 15 to 18 two-cell embryos per recipient.
Scar Size and Other Parameters for Tracking Left Ventricular Dysfunction after Induction of Myoca...
Scar Size and Other Parameters for Tracking Left Ventricular Dysfunction after Induction of Myoca...
In humans, cardiovascular disease (CVD) is the most frequent cause of death worldwide. Myocardial infarction (MI)is a leading cause of heart failure due to myocardial impairment, yet the progression of the resultant dysfunction is often undetected afte...
Surgical Treatment of Recurrent Rectal Prolapse in an Adult Female Black?crested Mangabey (Lophoc...
Surgical Treatment of Recurrent Rectal Prolapse in an Adult Female Black?crested Mangabey (Lophoc...
A 13-y-old, multiparous female black-crested mangabey (Lophocebus aterrimus) underwent surgical treatment for chronically recurring rectal prolapse by laparotomy and subsequent colopexy.
Humane Endpoints for Guinea Pigs Used for Mycobacterium tuberculosis Vaccine Research
Humane Endpoints for Guinea Pigs Used for Mycobacterium tuberculosis Vaccine Research
Guinea pigs are a commonly used model for tuberculosis vaccine research.
Cohousing Male Mice with and without Segmental Bone Defects
Cohousing Male Mice with and without Segmental Bone Defects
Spaceflight results in bone loss like that associated with osteoporosis or decreased weight-bearing (for example, high-energy trauma such as explosive injuries and automobile accidents).
Bias in Rating of Rodent Distress during Anesthesia Induction for Anesthesia Compared with Euthan...
Bias in Rating of Rodent Distress during Anesthesia Induction for Anesthesia Compared with Euthan...
Selection of an appropriate method of euthanasia involves balancing the wellbeing of the animal during the procedure with the intended use of the animal after death and the physical and psychologic safety of the observer or operator.
Characterization of Cotton Rat (Sigmodon hispidus) Eosinophils, Including Their Response to Respi...
Characterization of Cotton Rat (Sigmodon hispidus) Eosinophils, Including Their Response to Respi...
Eosinophils have been postulated to play a protective role against infection with respiratory syncytial virus (RSV), increase the severity of allergic asthma during respiratory viral infection, and drive vaccine-enhanced disease.
Updated Review of Fish Analgesia
Updated Review of Fish Analgesia
Analgesics are an integral part of routine pain management in mammals, yet their use in fish is still limited. Some recommendations on the use of analgesics in fish are currently in the literature; however, information on the properties of analgesic dr...
Content loaded within last 14 daysEffects of Fenbendazole-impregnated Feed and Topical Moxidectin...
Content loaded within last 14 daysEffects of Fenbendazole-impregnated Feed and Topical Moxidectin...
To protect the biosecurity of research rodent colonies, research institutions frequently require a quarantine period for live animals transferred into their facilities. Quarantine practices often include antibiotic and antiparasitic treatment with drug...
Effect of Chronic Social Stress on Prenatal Transfer of Antitetanus Immunity in Captive Breeding ...
Effect of Chronic Social Stress on Prenatal Transfer of Antitetanus Immunity in Captive Breeding ...
Because tetanus can cause significant morbidity and mortality in NHP, colonywide vaccination with tetanus toxoid is recommended for outdoor breeding colonies of rhesus macaques, with primary immunizations commonly given to infants at 6 mo of age follow...
Evaluation of 6 Methods for Aerobic Bacterial Sanitization of Smartphones
Evaluation of 6 Methods for Aerobic Bacterial Sanitization of Smartphones
Smartphones are ubiquitous devices that offer a variety of useful applications for human and veterinary medical professionals and the biomedical research community. Smartphones can serve as fomites and potentially transmit pathogens, including bacteria...