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Characterization of Demodex musculi Infestation, Associated Comorbidities, and Topographic Distri...
Characterization of Demodex musculi Infestation, Associated Comorbidities, and Topographic Distri...
A colony of B6.Cg-Rag1tm1Mom Tyrp1B-w Tg(Tcra,Tcrb)9Rest (TRP1/TCR) mice presented with ocular lesions and ulcerative dermatitis. Histopathology, skin scrapes, and fur plucks confirmed the presence of Demodex spp. in all clinically affected and subclin...
Population Genetic Structure of the Cayo Santiago Colony of Rhesus Macaques (Macaca mulatta)
Population Genetic Structure of the Cayo Santiago Colony of Rhesus Macaques (Macaca mulatta)
The rhesus macaque population at Cayo Santiago increases annually and is in urgent need of control. In-depth assessments of the colony�s population genetic and pedigree structures provide a starting point for improving the colony�s long-term management...
Viral Vector Biosafety in Laboratory Animal Research
Viral Vector Biosafety in Laboratory Animal Research
Viral vector research presents unique occupational health and safety challenges to institutions due to the rapid development of both in vivo and in vitro gene-editing technologies.
Automated Tracking of Motion and Body Weight for Objective Monitoring of Rats in Colony Housing
Automated Tracking of Motion and Body Weight for Objective Monitoring of Rats in Colony Housing
Living together in large social communities within an enriched environment stimulates self-motivated activity in rats. We developed a modular housing system in which a single unit can accommodate as many as 48 rats and contains multiple functional area...
Anesthetic and Postanesthetic Effects of Alfaxalone�Butorphanol Compared with Dexmedetomidine�Ket...
Anesthetic and Postanesthetic Effects of Alfaxalone�Butorphanol Compared with Dexmedetomidine�Ket...
Effective and safe anesthetic protocols are required for a variety of surgical and diagnostic procedures in chinchillas.
Iohexol Clearance for Determination of Glomerular Filtration Rate in Cynomolgus Monkeys (Macaca f...
Iohexol Clearance for Determination of Glomerular Filtration Rate in Cynomolgus Monkeys (Macaca f...
The purpose of this study was to validate a method for determine the glomerular filtration rate (GFR) in healthy cynomolgus monkeys by using iohexol.
Effects of Chronic Diurnal Disruption and Acute Inflammatory Challenge on Mice with Latent Murine...
Effects of Chronic Diurnal Disruption and Acute Inflammatory Challenge on Mice with Latent Murine...
People who engage in shift work (SW) have increased risk of developing illnesses, including infectious diseases and various inflammatory conditions. We hypothesized that exposure to repeated cycles of diurnal disruption, mimicking SW, influences viral ...
Evaluation of Pain Assessment Techniques and Analgesia Efficacy in a Female Guinea Pig (Cavia por...
Evaluation of Pain Assessment Techniques and Analgesia Efficacy in a Female Guinea Pig (Cavia por...
Guinea pigs (Cavia porcellus) are a frequently used species in research, often involving potentially painful procedures. Therefore, evidence-based recommendations regarding analgesia are critically needed to optimize their wellbeing.
An Efficient, Simple, and Noninvasive Procedure for Genotyping Aquatic and Nonaquatic Laboratory ...
An Efficient, Simple, and Noninvasive Procedure for Genotyping Aquatic and Nonaquatic Laboratory ...
Various animal models are indispensible in biomedical research. Increasing awareness and regulations have prompted the adaptation of more humane approaches in the use of laboratory animals. With the development of easier and faster methodologies to gen...
Effects of Time and Storage Conditions on the Chemical and Microbiologic Stability of Diluted Bup...
Effects of Time and Storage Conditions on the Chemical and Microbiologic Stability of Diluted Bup...
Buprenorphine is a partial ?-opioid agonist used for analgesia. Due to the small size of laboratory rodents, buprenorphine HCl is typically diluted 10- or 20-fold with a sterile diluent, such as saline, for accurate dosing. Protocols for preparing and ...
Pharmacokinetics of a Novel, Transdermal Fentanyl Solution in Rhesus Macaques (Macaca mulatta)
Pharmacokinetics of a Novel, Transdermal Fentanyl Solution in Rhesus Macaques (Macaca mulatta)
Rhesus macaques (Macaca mulatta) are the most commonly used NHP biomedical model and experience both research and clinical procedures requiring analgesia. Opioids are a mainstay of analgesic therapy. A novel, transdermal fentanyl solution (TFS) has bee...
Optimization of Glioblastoma Mouse Orthotopic Xenograft Models for Translational Research
Optimization of Glioblastoma Mouse Orthotopic Xenograft Models for Translational Research
Glioblastoma is an aggressive primary brain tumor predominantly localized to the cerebral cortex. We developed a panel of patient-derived mouse orthotopic xenografts (PDOX) for preclinical drug studies by implanting cancer stem cells (CSC) cultured fro...
Elo-rating for Tracking Rank Fluctuations after Demographic Changes Involving Semi-free ranging R...
Elo-rating for Tracking Rank Fluctuations after Demographic Changes Involving Semi-free ranging R...
Rhesus macaques (Macaca mulatta) are gregarious primates that form despotic societies characterized by frequent and intense aggression. Within long-term social groups, demographic changes may influence hierarchical stability, potentially resulting in c...
Echocardiographic Parameters of Clinically Normal Geriatric Rhesus Macaques (Macaca mulatta)
Echocardiographic Parameters of Clinically Normal Geriatric Rhesus Macaques (Macaca mulatta)
The goal of this study was to generate reference intervals for echocardiographic variables in a population of clinically normal geriatric rhesus macaques (Macaca mulatta). To do this, we studied 51 animals (age, 18�29 y; weight, 5.24�17.04 kg).
Effect of Early-life Gut Mucosal Compromise on Disease Progression in NOD Mice
Effect of Early-life Gut Mucosal Compromise on Disease Progression in NOD Mice
Disease expression in spontaneous nonobese diabetic (NOD) mice depends on environmental stimuli such as stress, diet, and gut microbiota composition.
The Interplay of Ethics, Animal Welfare, and IACUC Oversight on the Reproducibility of Animal Stu...
The Interplay of Ethics, Animal Welfare, and IACUC Oversight on the Reproducibility of Animal Stu...
Reproducibility in animal studies has been defined as the ability of a result to be replicated through independent experiments within the same or among different laboratories. Over the past few years, much has been written and said about the lack of re...
Diaphragmatic Hernia of the Stomach with Gastric Rupture in a Domestic Pig
Diaphragmatic Hernia of the Stomach with Gastric Rupture in a Domestic Pig
A 5.5-mo-old castrated, male Red Duroc pig presented acutely with depression and abdominal pain 9 d after an altercation with another pig. A CT examination indicated right pneumothorax and herniation of the stomach into the thoracic cavity. Due to a po...
Intraperitoneal Administration of Ethanol as a Means of Euthanasia for Neonatal Mice (Mus musculus)
Intraperitoneal Administration of Ethanol as a Means of Euthanasia for Neonatal Mice (Mus musculus)
The humane euthanasia of animals in research is of paramount importance. Neonatal mice frequently respond differently to euthanasia agents when compared with adults.
Effects of Racecadotril on Weight Loss and Diarrhea Due to Human Rotavirus in Neonatal Gnotobioti...
Effects of Racecadotril on Weight Loss and Diarrhea Due to Human Rotavirus in Neonatal Gnotobioti...
Diarrheal disease is the second leading cause of death in children younger than 5 y, and the most common cause of acute watery diarrhea in young children worldwide is rotaviral infection.
Effects of Human Management Events on Conspecific Aggression in Captive Rhesus Macaques
Effects of Human Management Events on Conspecific Aggression in Captive Rhesus Macaques
Conspecific aggression in outdoor-housed rhesus macaques (Macaca mulatta) at primate research facilities is a leading source of trauma and can potentially influence animal wellbeing and research quality. Although aggression between macaques is a normal...
Helicobacter Infection Significantly Alters Pregnancy Success in Laboratory Mice
Helicobacter Infection Significantly Alters Pregnancy Success in Laboratory Mice
Helicobacter spp. are gram-negative, helically shaped bacteria that cause gastric and enterohepatic infections in mammalian species. Although Helicobacter infection frequently is implicated to interfere with reproductive success, few experimental data ...
Uses and Doses of Local Anesthetics in Fish, Amphibians, and Reptiles
Uses and Doses of Local Anesthetics in Fish, Amphibians, and Reptiles
Local anesthetics are an integral part of routine pain management in mammals, yet their use is relatively limited in fish, amphibians and reptiles.
Effect of Overcrowding on Hair Corticosterone Concentrations in Juvenile Male Wistar Rats
Effect of Overcrowding on Hair Corticosterone Concentrations in Juvenile Male Wistar Rats
In many species, chronic stress due to overcrowding during the juvenile period triggers several metabolic and behavioral pathologies in adulthood. The aim of this study was to determine whether a chronic stress condition (overcrowding) induces changes ...
The Interplay of Ethics, Animal Welfare, and IACUC Oversight on the Reproducibility of Animal Stu...
The Interplay of Ethics, Animal Welfare, and IACUC Oversight on the Reproducibility of Animal Stu...
Reproducibility in animal studies has been defined as the ability of a result to be replicated through independent experiments within the same or among different laboratories.
Developing a Performance Standard for Adequate Sanitization of Wire-Bar Lids
Developing a Performance Standard for Adequate Sanitization of Wire-Bar Lids
The wire-bar lids on rodent cages are an integral part of the microenvironment and as such can impact rodent health and wellbeing. The Guide for the Care and Use of Laboratory Animals recommends changing wire-bar lids every other week but does not incl...
Genetic Characterization of a Captive Colony of Pigtailed Macaques (Macaca nemestrina)
Genetic Characterization of a Captive Colony of Pigtailed Macaques (Macaca nemestrina)
Effective colony management is critical to guarantee the availability of captive NHP as subjects for biomedical research. Pigtailed macaques (Macaca nemestrina) are an important model for the study of human and nonhuman primate diseases and behavior. J...
Personal Protective Equipment in Animal Research
Personal Protective Equipment in Animal Research
The occupational health and safety program is an integral component of a comprehensive animal care and use program. It is important to mitigate the risk of exposures of animal care and research personnel to allergens and physical, chemical, radiologic,...
Pharmacokinetics of Single-dose Subcutaneous Meloxicam Injections in Black-tailed Prairie Dogs (C...
Pharmacokinetics of Single-dose Subcutaneous Meloxicam Injections in Black-tailed Prairie Dogs (C...
This study evaluated the pharmacokinetic profile of a single dose of meloxicam (1.0 mg/kg) administered subcutaneously (n = 6) or intravenously (n = 2) to black-tailed prairie dogs (Cynomys ludovicianus). Blood was collected immediately before (time 0)...
Age-Associated Differences in Hematopoietic Stem and Progenitor Cells of Mice
Age-Associated Differences in Hematopoietic Stem and Progenitor Cells of Mice
Establishing the appropriate yet minimal number of control mice for experiments is a critical step in experimental design. This decision is particularly important regarding the study of the hematopoietic system over time, given various age-associated c...
Effects of Water Bottle Materials and Filtration on Bisphenol A Content in Laboratory Animal Drin...
Effects of Water Bottle Materials and Filtration on Bisphenol A Content in Laboratory Animal Drin...
Bisphenol A (BPA) is widely used in the polycarbonate plastics and epoxy resins that are found in laboratory animal husbandry materials including cages and water bottles. Concerns about BPA exposure in humans has led to investigations that suggest phys...
Quantification of Induced Hypothermia from Aseptic Scrub Applications during Rodent Surgery Prepa...
Quantification of Induced Hypothermia from Aseptic Scrub Applications during Rodent Surgery Prepa...
Laboratory mice (Mus musculus) are prone to develop hypothermia during anesthesia for surgery, thus potentially impeding anesthetic recovery, wound healing, and future health.
Review of CO2 as a Euthanasia Agent for Laboratory Rats and Mice
Review of CO2 as a Euthanasia Agent for Laboratory Rats and Mice
Selecting an appropriate, effective euthanasia agent is controversial. Several recent publications provide clarity on the use of CO2 in laboratory rats and mice. This review examines previous studies on CO2 euthanasia and presents the current body of k...
What Goes Around Can Come Around: An Unexpected Deleterious Effect of Using Mouse Running Wheels ...
What Goes Around Can Come Around: An Unexpected Deleterious Effect of Using Mouse Running Wheels ...
Environmental enrichment items such as running wheels can promote the wellbeing of laboratory mice. Growing evidence suggests that wheel running simulates exercise effects in many mouse models of human conditions, but this activity also might change ot...
Institutional Oversight of Occupational Health and Safety for Research Programs Involving Biohazards
Institutional Oversight of Occupational Health and Safety for Research Programs Involving Biohazards
Research with hazardous biologic materials (biohazards) is essential to the progress of medicine and science. The field of microbiology has rapidly advanced over the years, partially due to the development of new scientific methods such as recombinant ...
A Simple Way to Eradicate Methicillin�Resistant Staphylococcus aureus in Cynomolgus Macaques (Mac...
A Simple Way to Eradicate Methicillin�Resistant Staphylococcus aureus in Cynomolgus Macaques (Mac...
Our investigation of indoor-housed cynomolgus macaques (Macaca fascicularis) by using automated identification followed by antibiotic susceptibility testing revealed 1 of 7 immunocompetent animals and 2 of 9 immunosuppressed monkeys as carriers of meth...
Minimum Alveolar Concentration and Cardiopulmonary Effects of Isoflurane in Ring-tailed Lemurs (L...
Minimum Alveolar Concentration and Cardiopulmonary Effects of Isoflurane in Ring-tailed Lemurs (L...
The goal of this study was to determine the minimum alveolar concentration (MAC) and cardiopulmonary effects of isoflurane in ring-tailed lemurs (Lemur catta).
Differences in Vascular Response between Balloon Overstretch and Stent Overexpansion in Nonathero...
Differences in Vascular Response between Balloon Overstretch and Stent Overexpansion in Nonathero...
Which preclinical models are best suited for restenosis research remains uncertain. Here we compared the restenotic responses after balloon or stent overstretch injury in a porcine coronary artery.
Immune Activation of Platelets in Response to Serial Phlebotomy in Pigtailed Macaques (Macaca nem...
Immune Activation of Platelets in Response to Serial Phlebotomy in Pigtailed Macaques (Macaca nem...
Serial phlebotomy is a common sampling practice for repeated-measures studies in biomedical research. In NHP, the effect of serial blood collection on RBC parameters has been characterized, but the effects on platelet parameters and other aspects of th...
Antimicrobial Stewardship in Laboratory Animal Facilities
Antimicrobial Stewardship in Laboratory Animal Facilities
Bacterial resistance to antimicrobial drugs has become a global health crisis. Physicians and veterinarians are embracing the concept of 'antimicrobial stewardship' (AMS) to preserve the efficacy of antibiotics for future generations.
Content loaded within last 14 daysThe Interplay of Ethics, Animal Welfare, and IACUC Oversight on...
Content loaded within last 14 daysThe Interplay of Ethics, Animal Welfare, and IACUC Oversight on...
Reproducibility in animal studies has been defined as the ability of a result to be replicated through independent experiments within the same or among different laboratories. Over the past few years, much has been written and said about the lack of re...
Use of Microcomputed Tomography to Measure the Relaxin-induced Expansion of Intrapubic Ligaments ...
Use of Microcomputed Tomography to Measure the Relaxin-induced Expansion of Intrapubic Ligaments ...
Relaxin is a 6-kDa peptide in the insulin superfamily of hormones. In addition to its effects on reproductive and musculoskeletal ligaments, relaxin has demonstrated beneficial effects on cardiac, renal, and vascular systems in preclinical models.
Influence of Chronic Exposure to Simulated Shift Work on Disease and Longevity in Disease-Prone I...
Influence of Chronic Exposure to Simulated Shift Work on Disease and Longevity in Disease-Prone I...
Shift work (SW) is viewed as a risk factor for the development of many serious health conditions, yet prospective studies that document such risks are rare.
Spontaneous Development of Cutaneous Squamous Cell Carcinoma in Mice with Cellspecific Deletion o...
Spontaneous Development of Cutaneous Squamous Cell Carcinoma in Mice with Cellspecific Deletion o...
The deletion of NF?B in epithelial tissues by using skin-specific promoters can cause both tumor formation and severe inflammatory dermatitis, indicating that this signaling pathway is important for the maintenance of immune homeostasis in epithelial t...
Shope Fibroma in the External Ear Canal of a Domestic Rabbit
Shope Fibroma in the External Ear Canal of a Domestic Rabbit
A 5-y-old, intact, 2.5-kg female domestic rabbit was presented because of blood spatter on the wall of its cage and the toenails of its right hind limb. Physical examination revealed a red, gelatinous mass that spanned the width of the right vertical e...
Considerations When Writing and Reviewing a Higher Education Teaching Protocol Involving Animals
Considerations When Writing and Reviewing a Higher Education Teaching Protocol Involving Animals
The targeted use of animals in teaching at institutions of higher learning is fundamental to educating the next generation of professionals in the biologic and animal sciences.
Comparison of Antemortem and Environmental Samples for Zebrafish Health Monitoring and Quarantine
Comparison of Antemortem and Environmental Samples for Zebrafish Health Monitoring and Quarantine
Molecular diagnostic assays offer both exquisite sensitivity and the ability to test a wide variety of sample types. Various types of environmental sample, such as detritus and concentrated water, might provide a useful adjunct to sentinels in routine ...
A Redesign Approach for Improving Animal Care Services for Researchers
A Redesign Approach for Improving Animal Care Services for Researchers
Because a research institution�s animal care and use program oversees the provision of services specified in approved protocols designed by researchers, the effective provision of services within these programs is paramount to ensuring the humane care ...
Horner Syndrome in 2 Pigs (Sus scrofa) after Vascular Grafting of the Carotid Artery and Jugular ...
Horner Syndrome in 2 Pigs (Sus scrofa) after Vascular Grafting of the Carotid Artery and Jugular ...
The term Horner syndrome refers to the clinical presentation of oculosympathoparesis, comprising miosis, ptosis, and facial anhydrosis.
Behavioral Characteristics of Adult Zebrafish (Danio rerio) after MS222 Anesthesia for Fin Excision
Behavioral Characteristics of Adult Zebrafish (Danio rerio) after MS222 Anesthesia for Fin Excision
The health of laboratory animals is an ethical responsibility of researchers and a critical determinant of experimental outcome. Therefore, all husbandry procedures should be evaluated for their effects on mortality, behavior, and physiology to maximiz...
Comparison of 6 Injectable Anesthetic Regimens and Isoflurane in Gray Short?tailed Opossums (Mono...
Comparison of 6 Injectable Anesthetic Regimens and Isoflurane in Gray Short?tailed Opossums (Mono...
Gray short-tailed opossums are used in a wide variety of research in the areas of developmental biology, oncology, immunology, and comparative biology. Despite many frequent experimental manipulations of these animals under anesthesia, few studies to d...
Age- and Sex-associated Differences in Phenotypic and Functional Characteristics of Peripheral Bl...
Age- and Sex-associated Differences in Phenotypic and Functional Characteristics of Peripheral Bl...
Chimpanzees are the closest phylogenetic relatives to humans, sharing more than 98% genetic sequence identity.
Effects of Colored Enrichment Devices on Circadian Metabolism and Physiology in Male Sprague�Dawl...
Effects of Colored Enrichment Devices on Circadian Metabolism and Physiology in Male Sprague�Dawl...
Environmental enrichment (EE) gives laboratory animals opportunities to engage in species-specific behaviors. However, the effects of EE devices on normal physiology and scientific outcomes must be evaluated. We hypothesized that the spectral transmitt...
Comparison of Atipamezole with Yohimbine for Antagonism of Xylazine in Mice Anesthetized with Ket...
Comparison of Atipamezole with Yohimbine for Antagonism of Xylazine in Mice Anesthetized with Ket...
The ?2 adrenergic agonist xylazine produces a sedative effect and is typically combined with ketamine and used for anesthesia or chemical restraint of laboratory mice. Xylazine's sedative effect�and its undesirable side effects of bradycardia, hypotens...
Content loaded within last 14 daysEffects of Racecadotril on Weight Loss and Diarrhea Due to Huma...
Content loaded within last 14 daysEffects of Racecadotril on Weight Loss and Diarrhea Due to Huma...
Diarrheal disease is the second leading cause of death in children younger than 5 y, and the most common cause of acute watery diarrhea in young children worldwide is rotaviral infection. Medicines to specifically reduce diarrhea would be a desirable a...
Personal Protective Equipment in Animal Research
Personal Protective Equipment in Animal Research
The occupational health and safety program is an integral component of a comprehensive animal care and use program. It is important to mitigate the risk of exposures of animal care and research personnel to allergens and physical, chemical, radiologic,...
A Device that Allows Rodents to Behaviorally Thermoregulate when Housed in Vivariums
A Device that Allows Rodents to Behaviorally Thermoregulate when Housed in Vivariums
Laboratories and vivariums typically are maintained at ambient temperatures of 20 to 24 �C, leading to cold stress in mice. When mice are inactive and sleeping during the light phase, their zone of thermoneutrality associated with a basal metabolic rat...
Animal Models of Ebolavirus Infection
Animal Models of Ebolavirus Infection
Ebola virus is a highly pathogenic member of the family Filoviridae that causes a severe hemorrhagic disease in humans and NHP. The 2013�2016 West African outbreak has increased interest in the development and refinement of animal models of Ebola virus...
Tranexamic Acid and Supportive Measures to Treat Wasting Marmoset Syndrome
Tranexamic Acid and Supportive Measures to Treat Wasting Marmoset Syndrome
Wasting marmoset syndrome (WMS) has high incidence and mortality rates and is one of the most important problems in captive common marmoset (Callithrix jacchus) colonies. Despite several reports on WMS, little information is available regarding its rel...
Sequelae of Occult Aggression Disqualifying Young, Socially Housed, Female New Zealand White Rabb...
Sequelae of Occult Aggression Disqualifying Young, Socially Housed, Female New Zealand White Rabb...
International animal welfare organizations and federal, regional, and institutional oversight bodies encourage social housing of gregarious species, such as New Zealand white rabbits (Oryctolagus cuniculus), to promote animal wellbeing in research, tea...
Effect of Wearing a Telemetry Jacket on Behavioral and Physiologic Parameters of Dogs in the Open...
Effect of Wearing a Telemetry Jacket on Behavioral and Physiologic Parameters of Dogs in the Open...
Safety pharmacology studies in dogs often integrate behavioral assessments made using video recording with physiologic measurements collected by telemetry. However, whether merely wearing the telemetry vest affects canine behavior and other parameters ...
Lack of Effect of Murine Astrovirus Infection on Dextran Sulfate�induced Colitis in NLRP3-deficie...
Lack of Effect of Murine Astrovirus Infection on Dextran Sulfate�induced Colitis in NLRP3-deficie...
Murine astrovirus (MuAstV) is a recently identified, widespread infection among laboratory mice. MuAstV is found predominantly in the gastrointestinal tract of mice. Human and turkey astroviruses have been shown to disrupt tight junctions in the intest...
The Social Nature of European Rabbits
The Social Nature of European Rabbits
Increasing concerns regarding the wellbeing of laboratory animals have caused biomedical research stakeholders to reconsider traditional housing of laboratory species and to provide social companionship for social species. European rabbits (Oryctolagus...
Novel H-shunt Venovenous Bypass for Liver Transplantation in Cynomolgus Macaques
Novel H-shunt Venovenous Bypass for Liver Transplantation in Cynomolgus Macaques
Cynomolgus monkeys are often used in preclinical transplantation research. Performing liver transplantation in cynomolgus monkeys is challenging because they poorly tolerate portal vein clamping during the anhepatic phase.