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Humane Endpoints for Guinea Pigs Used for Mycobacterium tuberculosis Vaccine Research
Humane Endpoints for Guinea Pigs Used for Mycobacterium tuberculosis Vaccine Research
Guinea pigs are a commonly used model for tuberculosis vaccine research. Loss of body weight is the most frequently described humane endpoint for animals used in these studies. During a chronic study, we noted labored breathing in some tuberculosis-inf...
Effect of Prepregnancy Obesity on Litter Size in Primiparous Minipigs
Effect of Prepregnancy Obesity on Litter Size in Primiparous Minipigs
Obesity is a public health problem in both developed and developing countries, and the negative effects of obesity on reproductive physiology have been highlighted recently.
Animal Models of Aspergillosis
Animal Models of Aspergillosis
Aspergillosis is an airborne fungal disease caused by Aspergillus spp., a group of ubiquitous molds. This disease causes high morbidity and mortality in both humans and animals.
Repair of a Large Ventral Hernia in a Rhesus Macaque (Macaca mulatta) by Using an Abdominal Compo...
Repair of a Large Ventral Hernia in a Rhesus Macaque (Macaca mulatta) by Using an Abdominal Compo...
Here we present a 32-y-old rhesus macaque (Macaca mulatta) with a large recurrent ventral incisional hernia. The initial surgery included midline celiotomy for treatment of endometriosis, in which the animal developed a hernia that was repaired with in...
Analgesic Efficacy of Subcutaneous�Oral Dosage of Tramadol after Surgery in C57BL/6J Mice
Analgesic Efficacy of Subcutaneous�Oral Dosage of Tramadol after Surgery in C57BL/6J Mice
This study investigated the analgesic activity of tramadol in female C57BL/6J mice by using a single subcutaneous injection (25 mg/kg) of tramadol combined with the same dose given in drinking water for 24 h. We then evaluated the pharmacokinetics of t...
Comparison of Etomidate, Benzocaine, and MS222 Anesthesia with and without Subsequent Flunixin Me...
Comparison of Etomidate, Benzocaine, and MS222 Anesthesia with and without Subsequent Flunixin Me...
Often few alternative anesthetics for exotic species are available, due to the small numbers of these animals used in research.In this study, we evaluated the depth and duration of anesthesia in Xenopus laevis after their immersion in 3 doses of etomid...